Prader-Willi Syndrome (PWS)

PWS is a complex multisystem neurodevelopmental disorder with a neonatal incidence of approximately 1/16000. The underlying cause of PWS is a loss of genetically imprinted gene expression on chromosomes 15q11-q13. These genetic abnormalities lead to a unique phenotype, including mild to moderate intellectual disability, compulsive behavior, growth hormone deficiency, life-threatening appetite, and high risk of obesity.